ʻElua a ʻehā paha injections o ka platelet-rich plasma i loko o ke kuli osteoarthritis ʻaʻole i hoʻololi i nā biomarkers synovial, akā ua hoʻomaikaʻi pū i nā hopena lapaʻau.
Wahi a ka hoʻāʻo ʻana o nā loea ʻoihana kūpono, ua hoʻohālikelike lākou i ʻelua a me ʻehā intra-articular injections o ka platelet-rich plasma (PRP) e pili ana i nā loli i nā cytokines synovial a me nā hopena lapaʻau.Ua loaʻa i nā maʻi he 125 me ka osteoarthritis kuli (OA) i nā inikini PRP i kēlā me kēia 6 pule.Ma mua o kēlā me kēia PRP injection, ua hōʻiliʻili ʻia nā manaʻo wai synovial no ke aʻo ʻana.Ua māhele ʻia nā maʻi i ʻelua a ʻehā paha intra-articular PRP injections (nā hui A a me B, kēlā me kēia).Ua hoʻohālikelike ʻia nā hoʻololi i nā biomarkers synovial i nā pae kumu ma nā hui ʻelua, a ua loiloi ʻia nā hopena lapaʻau a hiki i hoʻokahi makahiki.
He kanaiwakūmāhā mau maʻi i hoʻopau i ka hōʻiliʻili wai synovial i loko o ka loiloi hope loa, 51 i ka hui A a me 43 i ka hui B. ʻAʻohe ʻokoʻa i ka makahiki mean, ka wahine, ka helu kino kino (BMI), a me ka radiographic OA grade.ʻO ka nui o ka helu platelet a me ka helu keʻokeʻo keʻokeʻo ma PRP he 430,000 / µL a me 200 / µL, kēlā me kēia. -4, IL-10, IL-13, a me IL-1RA) ʻaʻole i hoʻololi ʻia, a ʻo nā kumu ulu (TGF-B1, VEGF, PDGF-AA a me PDGF-BB) aia ma ka papa kuhikuhi a ma waena o 6 mau pule i ka hui A a me 18 wiki ma ka hui B.
Ua hoʻomaikaʻi maikaʻi ʻia nā hopena maʻi ma nā hui ʻelua mai nā wiki 6, me ka Visual Analog Scale (VAS), Patient Reported Outcome Measures [PROMs;ʻO Western Ontario a me McMaster Universities Osteoarthritis (WOMAC) Index a me Short Form-12 (SF-12)], nā ana hana hana [PBMs;ka manawa e ala ai (TUG), 5 mau ho'āʻo noho-kū (5 × SST), a me nā ho'āʻo hele wāwae 3-minute (3-minute WT)]. I ka hopena, 2 a i ʻole 4 intra-articular injections o PRP i kēlā me kēia 6 pule ma ke kuli. ʻAʻole i hōʻike ʻo OA i nā loli i nā cytokines synovial a me nā kumu ulu, akā ua hoʻomaikaʻi hou i nā hopena lapaʻau mai 6 mau pule a i 1 makahiki.
Ka manawa hoʻouna: Mar-03-2022