ʻO ka maʻi atrophic rhinitis mua (1Ry AR) he maʻi ihu maʻamau i hōʻike ʻia e ka nalowale o ka hana hoʻomaʻemaʻe mucociliary, ka hele ʻana o nā mea huna a me nā ʻōpala maloʻo, e alakaʻi ana i kahi pilau maʻamau, maʻamau bilateral.Ua hoʻāʻo ʻia ka nui o nā ʻano hana lapaʻau, akā ʻaʻohe manaʻo ʻae ʻia no ka mālama ʻana i ka holomua lōʻihi.ʻO ke kumu o kēia haʻawina ʻo ia ka loiloi i ka waiwai o ka platelet-rich plasma ma ke ʻano he mea hoʻoulu olaola no ka hoʻolalelale ʻana i ka rhinitis atrophic mua.
Ua hoʻokomo ka mea kākau i ka huina o 78 mau hihia i ʻike ʻia me ka rhinitis atrophic mua.Group A (hihia) a me nā mea maʻi me ka ilihune platelets underwent nasal endoscopy, Sino Nasal Outcome Test-25 ninau, saccharin manawa hookolokolo e loiloi mucosal ciliary clearance rate, a me ka plasma i biopsy specimen Group B (mana) 1 mahina a me 6 mahina ma mua o ka noi. ʻO ka plasma waiwai nui platelet.
ʻO nā hōʻailona maʻamau i ʻike ʻia e nā maʻi āpau ma ka Pūʻulu A ma mua o ka hoʻokomo ʻia ʻana o ka platelet rich plasma me ka nasal scab, ka mea i hōʻike i ka hoʻomaikaʻi ʻana o ka endoscopic a me ka hōʻemi ʻana i ka hanana, me 36 mau hihia (92.30%);footor, 31 (79.48%);Keakea ihu, 30 (76.92%);Pau ka pilau, 17 (43.58%);A epistaxis, 7 (17.94%) i ka nasal scab, 9 (23.07%);Ka wāwae, 13 (33.33%);Nasal congestion, 14 (35.89%);Pau ka pilau, 13 (33.33%);A epistaxis, 3 (7.69%), ma hope o 6 mahina, keia i hoike ia ma ka emi ana o ka Sino Nasal Outcome Test-25 helu, i averaged 40 ma mua platelet waiwai plasma a emi iho i 9 ma hope o 6 mahina.Pēlā nō, ua hoʻopōkole nui ʻia ka manawa hoʻomaʻemaʻe mucociliary ma hope o ka hoʻokomo ʻana o ka platelet rich plasma;ʻO ka awelika mua o ka hoʻāʻo ʻana i ka manawa lawe saccharin he 1980 kekona, a ua hoʻemi ʻia i 920 kekona 6 mau mahina ma hope o ka hoʻokomo ʻana i ka platelet rich plasma.
ʻO ka hoʻohana ʻana i ka platelet rich plasma ma ke ʻano he lāʻau olaola he ʻano hana hou liʻiliʻi invasive e hiki ke hoʻoponopono maikaʻi i ka pōʻino kino ma o ka noiʻi hou ʻana.
ʻEhā mau ala nui no ka mālama ʻana i ka rhinitis atrophic: hoʻoemi i ka lua ihu me nā ʻano mea like ʻole a me nā implants, ka hoʻoikaika ʻana i ka mucosal regeneration maʻamau me ka hoʻohana ʻana i ke ʻoki ʻana a i ʻole i hoʻololi ʻia ʻo Yang, lubricating i ka nasal mucosa, a i ʻole ka hoʻomaikaʻi ʻana i nā kīʻaha koko ihu.lua.Ua hoʻāʻo ʻia nā ʻano hana lapaʻau ʻē aʻe, e like me ka nasal irrigation a me ka flushing, glucose glycerol nasal drops, paraffin wai, estradiol i ka ʻaila pīkī, anti ozaena solution, antibiotics, hao, zinc, protein, vitamin supplements, vasodilators, prostheses, vaccines, placental extracts aiʻole acetylcholine, me ka pilocarpine a i ʻole.Eia naʻe, ʻokoʻa ka hopena o kēia mau ʻano.Ma ka hoʻomaʻamaʻa lapaʻau, ʻo ka holoi ʻana i ka lua ihu me ka nasal spray ka mea maʻamau i hoʻohana ʻia no ka mālama ʻana i nā hōʻailona o ka rhinitis atrophic, no ka mea hiki ke hoʻomaʻemaʻe i ka mucosa ihu a pale i ka scabbing.
Ma waena o nā kaʻina hana i luna, ua hōʻike ʻia ka hoʻomaʻamaʻa ʻana o Yang i kahi ala kūpono a lōʻihi no ka mālama ʻana i ka rhinitis atrophic.Eia naʻe, hiki i ka hanu waha hāmama ke hōʻeha nui i nā maʻi.Ua hōʻike ʻia nā lubricants a me nā mea hoʻohui i nā hopena liʻiliʻi a pōkole.No laila, ua aʻo ʻia nā ʻano hana ʻē aʻe e hāpai i ka hoʻōla hou ʻana o ka nasal mucosal a i ʻole angiogenesis.
PRPua haku ʻia me nā ʻano plasma i ʻoi aku ma mua o ka platelet concentration ma ke koko holoʻokoʻa.Hoʻonui ka PRP i nā mea e pili ana i ka ulu ʻana o ka ʻiʻo, ka ʻokoʻa, a me ka hoʻōla ʻana i ka ʻili, e like me ka platelet derived growth factor, transforming growth factor, fibroblast growth factor, endothelial growth factor, a me ka insulin-like growth factor.No laila, ua hōʻoia ʻia ʻo PRP i nā hopena maikaʻi i ʻae ʻia i nā noiʻi lapaʻau like ʻole, e hoʻoikaika maikaʻi ana i ka ho'ōla ʻana i ka ʻeha a me ka hoʻoulu hou ʻana o ka ʻiʻo, e komo pū me ka otolaryngology.ʻOi aku ka kikoʻī, ua hōʻike ʻia he maikaʻi ka PRP i ka hoʻomaikaʻi ʻana i ka hana hou ʻana o ka membrane tympanic, nā kaula leo a me ke aʻalolo maka, a me ka ho'ōla ʻana ma hope o ka myringoplasty a i ʻole endoscopic sinus surgery.Eia kekahi, ua hana ʻia kahi noiʻi hoʻokele i kekahi mau makahiki i hala aku nei no ka mālama ʻana i ka rhinitis atrophic me ka hoʻokomo ʻana i ka hui lipid PRP.Eia kekahi, hoʻohana ʻo PRP i ke koko autologous a ʻaʻohe mea maʻi a i ʻole ka pale ʻana i ka pale.Hiki ke hoʻomākaukau maʻalahi i loko o kekahi mau minuke ma o nā kaʻina centrifugation ʻelua.
Ma kēia haʻawina, ua noiʻi mākou i ka hoʻokomo ʻana o ka PRP i loko o ka mucosa nasal atrophic, kahi i hoʻomaikaʻi ai i ka mucosal cilia clearance a me nā hōʻailona i ka manawa o ka hahai ʻana o 6 mau mahina, ʻoi aku hoʻi i nā maʻi ʻōpio, me nā hopena i hoʻohālikelike ʻia i ka hui kahiko.I nā hihia he nui o ka rhinitis atrophic, me ka rhinitis kahiko, hoʻemi ʻia ka huna ʻana o ka mucus.No laila, ʻo ka mānoanoa mucinous alakaʻi i ka hoʻopaneʻe ʻana o ka nasal mucosal cilia.ʻO ka hoʻopiha hou ʻana i ka wai ma o ka paʻakai paʻakai e hoʻopilikia i nā waiwai o ka mucus viscous, a e hoʻihoʻi ʻia ka hoʻomaʻemaʻe ʻana o ka nasal mucosa cilia i kekahi ʻano.Eia naʻe, hiki ke kaupalena ʻia ke kuleana o ka nasal mucus diluted i ka hoʻoponopono ʻana i nā hōʻailona o ka ihu.No laila, ʻoiai ʻo ka conservative nasal hydration hiki ke hoʻonui i ka mucociliary clearance, ʻaʻole i hoʻomaikaʻi maikaʻi kēia regimen lapaʻau i nā hōʻailona nasal.Eia kekahi, pono ka nasal spray a me ka irrigation i ka saline physiological a me nā mea hana kūikawā, a pono e hana mau ʻia e kāohi i nā hōʻailona.ʻO ka ʻokoʻa, koi wale ka PRP injection i hoʻokahi injection e loaʻa ai nā hopena maikaʻi.Ma hope o ka hoʻokomo ʻana, piʻi koke ka nui o ka turbinate.Eia nō naʻe, i ka huakaʻi maʻi maʻi hou (2 mau pule ma hope), ʻaʻohe ʻokoʻa o ka nui a me ke ʻano o ka turbinate haʻahaʻa.No laila, ʻo ka piʻi ʻana o ka leo ma muli o ka injection i manaʻo ʻia he mea ʻole.Eia kekahi, e like me ka mea i hōʻike ʻia ma ka sub domain analysis o SNOT-22, ʻaʻohe mea i hoʻomaikaʻi nui ʻia i ka manaʻo sub domain o nā maʻi maʻi PRP injection.ʻAʻole i hui pū ʻia nā hopena me ka hoʻomaikaʻi ʻana i ka manaʻo sub domain, e hōʻike ana ʻaʻole nui ka hopena placebo ma kekahi ʻano.Pono ka ʻūhā ihu a me ka irrigation i ka paʻakai physiological a me nā mea hana kūikawā, a pono e hana mau ʻia e kāohi i nā hōʻailona.ʻO ka ʻokoʻa, koi wale ka PRP injection i hoʻokahi injection e loaʻa ai nā hopena maikaʻi.Ma hope o ka hoʻokomo ʻana, piʻi koke ka nui o ka turbinate.Eia nō naʻe, i ka huakaʻi maʻi maʻi hou (2 mau pule ma hope), ʻaʻohe ʻokoʻa o ka nui a me ke ʻano o ka turbinate haʻahaʻa.No laila, ʻo ka piʻi ʻana o ka leo ma muli o ka injection i manaʻo ʻia he mea ʻole.Eia kekahi, e like me ka mea i hōʻike ʻia ma ka sub domain analysis o SNOT-22, ʻaʻohe mea i hoʻomaikaʻi nui ʻia i ka manaʻo sub domain o nā maʻi maʻi PRP injection.ʻAʻole i hui pū ʻia nā hopena me ka hoʻomaikaʻi ʻana i ka manaʻo sub domain, e hōʻike ana ʻaʻole nui ka hopena placebo ma kekahi ʻano.Pono ka ʻūhā ihu a me ka irrigation i ka paʻakai physiological a me nā mea hana kūikawā, a pono e hana mau ʻia e kāohi i nā hōʻailona.ʻO ka ʻokoʻa, koi wale ka PRP injection i hoʻokahi injection e loaʻa ai nā hopena maikaʻi.Ma hope o ka hoʻokomo ʻana, piʻi koke ka nui o ka turbinate.Eia nō naʻe, i ka huakaʻi maʻi maʻi hou (2 mau pule ma hope), ʻaʻohe ʻokoʻa o ka nui a me ke ʻano o ka turbinate haʻahaʻa.No laila, ʻo ka piʻi ʻana o ka leo ma muli o ka injection i manaʻo ʻia he mea ʻole.Eia kekahi, e like me ka mea i hōʻike ʻia ma ka sub domain analysis o SNOT-22, ʻaʻohe mea i hoʻomaikaʻi nui ʻia i ka manaʻo sub domain o nā maʻi maʻi PRP injection.ʻAʻole i hui pū ʻia nā hopena me ka hoʻomaikaʻi ʻana i ka manaʻo sub domain, e hōʻike ana ʻaʻole nui ka hopena placebo ma kekahi ʻano.Hoʻokahi hoʻokahi injection e loaʻa ai nā hopena maikaʻi.Ma hope o ka hoʻokomo ʻana, piʻi koke ka nui o ka turbinate.Eia nō naʻe, i ka huakaʻi maʻi maʻi hou (2 mau pule ma hope), ʻaʻohe ʻokoʻa o ka nui a me ke ʻano o ka turbinate haʻahaʻa.No laila, ʻo ka piʻi ʻana o ka leo ma muli o ka injection i manaʻo ʻia he mea ʻole.Eia kekahi, e like me ka mea i hōʻike ʻia ma ka sub domain analysis o SNOT-22, ʻaʻohe mea i hoʻomaikaʻi nui ʻia i ka manaʻo sub domain o nā maʻi maʻi PRP injection.ʻAʻole i hui pū ʻia nā hopena me ka hoʻomaikaʻi ʻana i ka manaʻo sub domain, e hōʻike ana ʻaʻole nui ka hopena placebo ma kekahi ʻano.Hoʻokahi hoʻokahi injection e loaʻa ai nā hopena maikaʻi.Ma hope o ka hoʻokomo ʻana, piʻi koke ka nui o ka turbinate.Eia nō naʻe, i ka huakaʻi maʻi maʻi hou (2 mau pule ma hope), ʻaʻohe ʻokoʻa o ka nui a me ke ʻano o ka turbinate haʻahaʻa.No laila, ʻo ka piʻi ʻana o ka leo ma muli o ka injection i manaʻo ʻia he mea ʻole.Eia kekahi, e like me ka mea i hōʻike ʻia ma ka sub domain analysis o SNOT-22, ʻaʻohe mea i hoʻomaikaʻi nui ʻia i ka manaʻo sub domain o nā maʻi maʻi PRP injection.ʻAʻole i hui pū ʻia nā hopena me ka hoʻomaikaʻi ʻana i ka manaʻo sub domain, e hōʻike ana ʻaʻole nui ka hopena placebo ma kekahi ʻano.ʻAʻohe ʻokoʻa i ka nui a me ke ʻano o ka turbinate haʻahaʻa.No laila, ʻo ka piʻi ʻana o ka leo ma muli o ka injection i manaʻo ʻia he mea ʻole.Eia kekahi, e like me ka mea i hōʻike ʻia ma ka sub domain analysis o SNOT-22, ʻaʻohe mea i hoʻomaikaʻi nui ʻia i ka manaʻo sub domain o nā maʻi maʻi PRP injection.ʻAʻole i hui pū ʻia nā hopena me ka hoʻomaikaʻi ʻana i ka manaʻo sub domain, e hōʻike ana ʻaʻole nui ka hopena placebo ma kekahi ʻano.ʻAʻohe ʻokoʻa i ka nui a me ke ʻano o ka turbinate haʻahaʻa.No laila, ʻo ka piʻi ʻana o ka leo ma muli o ka injection i manaʻo ʻia he mea ʻole.Eia kekahi, e like me ka mea i hōʻike ʻia ma ka sub domain analysis o SNOT-22, ʻaʻohe mea i hoʻomaikaʻi nui ʻia i ka manaʻo sub domain o nā maʻi maʻi PRP injection.ʻAʻole i hui pū ʻia nā hopena me ka hoʻomaikaʻi ʻana i ka manaʻo sub domain, e hōʻike ana ʻaʻole nui ka hopena placebo ma kekahi ʻano.
ʻAʻole koʻikoʻi ka ʻeha mau a me ka hōʻoluʻolu o ka rhinitis atrophic i ka lāʻau lapaʻau.No laila, hoʻemi ʻia nā poho socio-economic.Eia naʻe, mai ka manaʻo o nā mea maʻi maoli, he maʻi koʻikoʻi ia.Eia kekahi, me ka ʻelemakule o ka heluna kanaka, ke hoʻonui nei ka nui o nā maʻi me ka rhinitis senile i ka ulu nui.No laila, he mea nui ka hoʻolako ʻana i ka lāʻau kūpono no ka rhinitis atrophic, me ka rhinitis ʻelemakule.
ʻO ka pahuhopu o kēia noiʻi ʻana, ʻo ia ke noi ʻana i kahi ʻano hana hou no ka mālama ʻana i ka rhinitis atrophic ma o ka autologous PRP injection, a e hoʻohālikelike i ka hoʻomaikaʻi ʻana o nā hōʻailona ma waena o ka pūʻulu lapaʻau PRP a me ka hui mālama conservative me ka hoʻohana ʻana i kahi pūʻulu hoʻomalu.Ma muli o ka atrophic rhinitis he wehewehe lapaʻau, ʻoi aku ka nui o ka noiʻi ʻana e ʻike i kāna ʻano hana.Eia nō naʻe, i mea e pale ai i nā poho socio-economic a me ka emi ʻana o ka maikaʻi o ke ola o ka maʻi, pono e hāʻawi i nā hopena noiʻi me nā hopena therapeutic.
Eia naʻe, he mau palena kēia haʻawina.Ua hoʻolālā maikaʻi ʻia kēia haʻawina a ʻaʻole hiki ke hoʻomalu ʻia no ka mea ua hōʻole kekahi poʻe i ka papahana injection nasal.Ma ke ʻano o ka loina, pono e kaupalena ʻia nā hana invasive no nā kumu hoʻonaʻauao ma ka pūʻulu hoʻomalu e pale i nā kuleana a me nā pono o nā maʻi.No laila, ʻo ka hāʻawi ʻana i nā mea maʻi e pili ana i kā lākou makemake e ʻoi aku ka nāwaliwali o nā hopena noiʻi ma mua o nā mea i hāʻawi ʻia e nā haʻawina hoʻokele randomized.Eia kekahi, hoʻokumu ʻia ka rhinitis atrophic lua ma muli o ka deformation a me ka wehe ʻana o ka hale ihu kumu.ʻO ka hana ʻana i kahi biopsy hiki ke hoʻonui i ka atrophy.No laila, mai kahi hiʻohiʻona etika, ʻaʻole hiki ke hana i ka biopsy kiko ihu i nā maʻi me ka rhinitis atrophic.ʻAʻole hōʻike nā hopena ma hope o 6 mau mahina o ka hahai ʻana i nā hopena lōʻihi.Eia kekahi, he liʻiliʻi ka nui o nā maʻi i ka subgroup.No laila, pono e hoʻokomo i ka noiʻi e hiki mai ana i nā poʻe maʻi e hoʻohana ana i kahi hoʻolālā hoʻokele randomized ma kahi manawa lōʻihi.
（Paʻi hou ʻia nā mea o kēia ʻatikala, ʻaʻole mākou e hāʻawi i ka hōʻoiaʻiʻo a i ʻole ka hōʻoia ʻana no ka pololei, hilinaʻi a i ʻole ka piha o nā mea i loko o kēia ʻatikala, a ʻaʻole kuleana no nā manaʻo o kēia ʻatikala, e ʻoluʻolu e hoʻomaopopo.)
Ka manawa hoʻouna: Mei-23-2023