ʻO nā platelets, e like me nā ʻāpana cell mai nā megakaryocytes iwi iwi, ʻike ʻia e ka nele o ka nuclei.Loaʻa i kēlā me kēia pāpaʻi ʻekolu ʻano ʻāpana, ʻo ia hoʻi ʻo α Granules, nā kino paʻa a me nā lysosomes me nā nui like ʻole.Me ka α Ua waiwai nā granules ma mua o 300 mau proteins like ʻole, e like me ka vascular endothelial activating factor, leukocyte chemotactic factor, activating factor, tissue repair related growth factor a me antibacterial peptide, e pili ana i nā kaʻina hana physiological a me nā pathological, e like me ka ho'ōla ʻana i ka ʻeha. , angiogenesis a me ka pale ʻana i ka maʻi maʻi.
Aia i loko o ke kino ʻeleʻele nā kiʻekiʻe o ka adenosine diphosphate (ADP), adenosine triphosphate (ATP), Ca2+, Mg2+ a me 5-hydroxytryptamine.Loaʻa i nā Lysosomes nā ʻano protease kō, e like me glycosidases, protease, cationic proteins a me nā protein me ka hana bactericidal.Hoʻokuʻu ʻia kēia mau GF i ke koko ma hope o ka hoʻoulu ʻana o ka platelet.
Hoʻokumu ʻo GF i ka hopena cascade ma o ka hoʻopaʻa ʻana me nā ʻano ʻano like ʻole o ka cell membrane receptors, a hoʻāla i nā hana kikoʻī i ke kaʻina o ka hoʻōla hou ʻana.I kēia manawa, ʻo ka GF i aʻo nui ʻia ʻo ia ka platelet derived growth factor (PDGF) a me ka transforming growth factor (TGF- β （TGF-β）， Vascular endothelial growth factor (VEGF), epidermal growth factor (EGF), fibroblast growth factor (FGF), ʻO ka mea hoʻohui i ka ʻiʻo ulu (CTGF) a me ka insulin-like growth factor-1 (IGF-1) kōkua kēia mau GF i ka hoʻoponopono ʻana i ka ʻiʻo, tendon, ligament a me nā ʻiʻo ʻē aʻe ma o ka hoʻoikaika ʻana i ka hoʻonui ʻana o ka cell a me ka ʻokoʻa, angiogenesis a me nā kaʻina hana ʻē aʻe, a laila pāʻani i kahi mea like. kuleana.
Hoʻohana i ka PRP ma Vitiligo
ʻO Vitiligo, ma ke ʻano he maʻi autoimmune maʻamau, a me ka maʻi ʻili o ka ʻili, he hopena maikaʻi ʻole ia i ka psychology o nā maʻi a hoʻopilikia koʻikoʻi i ka maikaʻi o ke ola o nā maʻi.I ka hōʻuluʻuluʻana,ʻo ka hopena o ka vitiligo ka hopena o ka pilina o nā kumu genetic a me nā mea kaiapuni, kahi e hoʻoukaʻia ai nā melanocytesʻili a hōʻinoʻia e ka pūnaewele autoimmune.I kēia manawa, ʻoiai he nui nā lāʻau lapaʻau no ka vitiligo, ʻaʻole pinepine ka maikaʻi o lākou, a ʻaʻole nui nā lāʻau lapaʻau i hōʻike i ka lāʻau lapaʻau.I nā makahiki i hala iho nei, me ka ʻimi mau ʻana i ka pathogenesis o vitiligo, ua hoʻohana mau ʻia kekahi mau ʻano hana lapaʻau hou.Ma ke ʻano he ala kūpono e mālama ai i ka vitiligo, ua hoʻohana mau ʻia ka PRP.
I kēia manawa, ʻike nui ʻia ka 308 nm excimer laser a me 311 nm narrow band ultraviolet (NB-UVB) a me nā ʻenehana phototherapy ʻē aʻe no ko lākou pono i nā maʻi me ka vitiligo.I kēia manawa, ʻo ka hoʻohana ʻana i ka autologous PRP subcutaneous microneedle injection i hui pū ʻia me ka phototherapy i nā mea maʻi me stable vitiligo ua holomua nui.Abdelghani et al.loaʻa i kā lākou noiʻi ʻana i ka autologous PRP subcutaneous microneedle injection i hui pū ʻia me NB-UVB phototherapy hiki ke hoʻopōkole nui i ka manawa mālama o nā maʻi vitiligo.
Khattab et al.mālama ʻia nā maʻi me ka vitiligo non segmental paʻa me 308 nm excimer laser a me PRP, a loaʻa nā hopena maikaʻi.Ua ʻike ʻia ʻo ka hui pū ʻana o nā mea ʻelua hiki ke hoʻomaikaʻi maikaʻi i ka leucoplakia recolor rate, hoʻopōkole i ka manawa mālama, a pale i ka hopena ʻino o ka hoʻohana lōʻihi o ka 308 nm excimer laser irradiation.Hōʻike kēia mau haʻawina ʻo ka PRP i hui pū ʻia me ka phototherapy he ala kūpono no ka mālama ʻana i ka vitiligo.
Eia naʻe, ʻo Ibrahim a me nā haʻawina ʻē aʻe e hōʻike ana ʻaʻole pono ka PRP wale nō i ka mālama ʻana i ka vitiligo.Kadry et al.hana i ka randomized hoʻopaʻa haʻawina e pili ana i ka lapaau ana o vitiligo me PRP hui me carbon dioxide dot matrix laser, a ike i ka PRP hui me carbon dioxide dot matrix laser a me PRP wale nō i loaʻa i ka maikai kala reproduction hopena.Ma waena o lākou, ʻo ka PRP i hui pū ʻia me ka carbon dioxide dot matrix laser i loaʻa ka hopena hoʻohua kala maikaʻi loa, a ʻo PRP wale nō i loaʻa i ka hoʻohua kala ma ka leukoplakia.ʻOi aku ka maikaʻi o ka hoʻoulu kala ʻana o ka PRP wale nō ma mua o ka carbon dioxide dot matrix laser wale nō i ka mālama ʻana i ka vitiligo.
ʻO ka hana i hui pū ʻia me PRP i ka mālama ʻana o Vitiligo
ʻO Vitiligo kahi ʻano maʻi maʻi pigment i hōʻike ʻia e ka depigmentation.ʻO nā ʻano lapaʻau maʻamau ka lāʻau lapaʻau, phototherapy a i ʻole ke ʻoki ʻana, a i ʻole ka hui pū ʻana o nā ʻano lapaʻau lehulehu.No nā poʻe maʻi me ka vitiligo paʻa a me ka hopena maikaʻi ʻole o ka mālama maʻamau, hiki i ka lāʻau lapaʻau ke hana mua.
ʻO Garg et al.ua hoʻohana ʻo PRP ma ke ʻano he mea hoʻokuʻu o nā pūnaewele epidermal, a hoʻohana iā Er: YAG laser e wili i nā wahi keʻokeʻo, i loaʻa i ka hopena therapeutic maikaʻi i ka mālama ʻana i nā maʻi vitiligo paʻa.I loko o kēia haʻawina, ua kākau inoa ʻia nā maʻi 10 me ka vitiligo paʻa a ua loaʻa nā lesions 20.I loko o 20 lesions, 12 lesions (60%) hōʻike i ka hoʻihoʻi hou ʻana i ka puaʻa, 2 lesions (10%) i hōʻike i ka hoʻihoʻi hou ʻana i ka puaʻa, 4 mau ʻeha (20%) i hōʻike i ka hoʻihoʻi ʻana i ka puaʻa haʻahaʻa, a ʻo 2 lesions (10%) i hōʻike ʻole i ka hoʻomaikaʻi nui.ʻO ka hoʻihoʻi ʻana o nā wāwae, nā ami kuli, ka maka a me ka ʻāʻī he mea maopopo loa, ʻoiai ʻoi aku ka maikaʻi o ka hoʻihoʻi ʻana o nā hope.
Nimitha et al.ua hoʻohana i ka PRP hoʻokuʻu ʻana o nā pūnaewele epidermal e hoʻomākaukau i ka hoʻokuʻu ʻana a me ka hoʻopaʻa ʻana i ka phosphate buffer hoʻokuʻu o nā pūnaewele epidermal e hoʻohālikelike a nānā i kā lākou hoʻolaʻa puaʻa i nā maʻi me ka vitiligo paʻa.Ua hoʻokomo ʻia nā maʻi vitiligo 21 a ua loaʻa nā kiko keʻokeʻo 42.ʻO ka manawa paʻa o ka vitiligo he 4.5 mau makahiki.ʻO ka hapa nui o nā maʻi i hōʻike i ka hoʻihoʻi ʻana o ka puaʻa ʻāpana liʻiliʻi i ka oval ma kahi o 1-3 mau mahina ma hope o ka mālama ʻana.I loko o 6 mau mahina o ka hahai ʻana, ʻo 75.6% ka hoʻihoʻi ʻana o ka puaʻa ma ka pūʻulu PRP a me 65% ma ka pūʻulu PRP ʻole.He mea koʻikoʻi ka ʻokoʻa o ka wahi hoʻōla puaʻa ma waena o ka pūʻulu PRP a me ka pūʻulu PRP ʻole.Ua hōʻike ka pūʻulu PRP i ka hoʻihoʻi hou ʻana i ka pigment.I ka nānā ʻana i ka helu hoʻihoʻi o ka puaʻa i nā maʻi me ka vitiligo segmental, ʻaʻohe ʻokoʻa nui ma waena o ka pūʻulu PRP a me ka pūʻulu PRP ʻole.
Hoʻohana i ka PRP ma Chloasma
ʻO Melasma kahi ʻano o ka maʻi ʻili pigmented i loaʻa i ka maka, ka mea maʻamau i ka maka o nā wahine i ʻike pinepine ʻia i ke kukui ultraviolet a loaʻa ka ʻili hohonu.ʻAʻole i wehewehe piha ʻia kona pathogenesis, a paʻakikī ke mālama a maʻalahi hoʻi e hoʻi hou.I kēia manawa, hoʻohana ka mālama ʻana i ka chloasma i ke ʻano o ka mālama ʻana.ʻOiai ʻo ka subcutaneous injection o PRP he mau ʻano lapaʻau like ʻole no ka chloasma, ʻaʻole ʻoluʻolu loa ka maikaʻi o nā mea maʻi, a ua maʻalahi ka hoʻihoʻi ʻana ma hope o ka pau ʻana o ka mālama ʻana.A ʻo nā lāʻau lapaʻau waha e like me ka tranexamic acid a me ka glutathione hiki ke hoʻoulu i ka ʻōpū o ka ʻōpū, ka maʻi o ka menstrual cycle, headache, a me ka hoʻokumu ʻana i ka thrombosis vein hohonu.
ʻO ka ʻimi ʻana i kahi lāʻau lapaʻau hou no ka chloasma he kuhikuhi koʻikoʻi i ka noiʻi ʻana o chloasma.Ua hōʻike ʻia e hiki i ka PRP ke hoʻomaikaʻi nui i nā ʻili ʻili o nā maʻi me ka melasma.Cay ı rl ı Et al.Ua hōʻike ʻia ua loaʻa i kahi wahine 27 makahiki i ka subcutaneous microneedle injection o PRP i kēlā me kēia 15 lā.I ka pau ʻana o ke kolu o ka mālama ʻana i ka PRP, ua ʻike ʻia ʻo ka wahi o ka hoʻihoʻi ʻana o ka pigment epidermal he> 80%, a ʻaʻohe hoʻi hou i loko o 6 mau mahina.Sirithanabadeekul et al.ua hoʻohana i ka PRP no ka mālama ʻana i ka chloasma e hana i ka RCT ʻoi aku ka paʻakikī, ka mea i hōʻoia hou i ka pono o ka intracutaneous PRP injection no ka mālama ʻana i ka chloasma.
Hofny et al.ua hoʻohana i ke ʻano immunohistochemical e hana ai i ka TGF ma o ka subcutaneous microneedle injection o PRP i loko o nā ʻili ʻili o nā mea maʻi me ka chloasma a me nā ʻāpana maʻamau- β Ua hōʻike ʻia ka hoʻohālikelike o ka ʻōlelo protein ma mua o ka mālama ʻana i ka PRP, nā ʻili ʻili o nā maʻi me ka chloasma a me TGF a puni nā ʻili ʻili- β Ua emi loa ka ʻōlelo protein ma mua o ka ʻili olakino (P<0.05).Ma hope o ka mālama ʻana i ka PRP, TGF o nā ʻili ʻili i nā maʻi me ka chloasma-β Ua hoʻonui nui ʻia ka ʻōlelo protein.Hōʻike kēia hanana e hiki ke hoʻokō ʻia ka hopena hoʻomaikaʻi o ka PRP ma nā maʻi chloasma ma ka hoʻonui ʻana i ka TGF o nā ʻili ʻili- β Loaʻa ka ʻōlelo protein i ka hopena therapeutic ma chloasma.
Hoʻohui ʻia ka ʻenehana Photoelectric me Subcutaneous Injection o PRP no ka mālama ʻana iā Chloasma
Me ka hoʻomau mau ʻana o ka ʻenehana photoelectric, ʻo kāna kuleana i ka mālama ʻana i ka chloasma ua ʻoi aku ka nui o ka nānā ʻana o nā mea noiʻi.I kēia manawa, ʻo nā lasers i hoʻohana ʻia no ka mālama ʻana i ka chloasma e komo pū me ka laser Q-switched, ka laser lattice, ke kukui pulsed ikaika, ka laser cuprous bromide a me nā hana lapaʻau ʻē aʻe.ʻO ke kumumanaʻo, ʻo ia ka hoʻokō ʻana i ka puhi kukui koho no nā ʻāpana melanin i loko a i waena o nā melanocytes ma o ke koho ʻana i ka ikehu, a hoʻopau ʻia ka hana o nā melanocytes ma o ka haʻahaʻa haʻahaʻa a me ka hoʻoheheʻe ʻana i nā kukui he nui, a i ka manawa hoʻokahi, e hoʻoheheʻe nui ʻia nā ʻāpana melanin. Hoʻokō ʻia, hiki iā ia ke hoʻolilo i nā ʻāpana melanin i mea liʻiliʻi a ʻoi aku ka maikaʻi o ka moni ʻana a hoʻokuʻu ʻia e ke kino.
Su Bifeng et al.mālama ʻia ka chloasma me ka PRP wai māmā i hui pū ʻia me Q hoʻololi Nd: YAG 1064nm laser.Ma waena o nā maʻi 100 me ka chloasma, 15 mau maʻi ma ka hui PRP + laser i hoʻōla maoli ʻia, 22 mau mea maʻi i hoʻomaikaʻi nui ʻia, 11 mau maʻi i hoʻomaikaʻi ʻia, a ʻo 1 maʻi ʻaʻole pono;Ma ka hui laser wale nō, 8 mau hihia i ho'ōla maoli ʻia, 21 mau hihia i hōʻike maikaʻi ʻia, 18 mau hihia i hoʻomaikaʻi ʻia, a ʻo 3 mau hihia ʻaʻole pono.ʻO kaʻokoʻa ma waena o nā pūʻuluʻelua he mea nui (P<0.05).Ua hōʻoia hou ʻo Peng Guokai lāua ʻo Song Jiquan i ka pono o ka Q-switched laser i hui pū ʻia me PRP i ka mālama ʻana i ka chloasma maka.Ua hōʻike ʻia nā hopena i ka laser Q-switched i hui pū ʻia me PRP i kūpono i ka mālama ʻana i ka chloasma maka.
Wahi a ka noiʻi o kēia manawa e pili ana i ka PRP i nā dermatoses pigmented, ʻo ke ʻano o ka PRP i ka mālama ʻana i ka chloasma ʻo ia ka PRP e hoʻonui i ka TGF o nā ʻili ʻili- β Hiki i ka ʻōlelo protein ke hoʻomaikaʻi i nā maʻi melasma.ʻO ka hoʻomaikaʻi ʻana o ka PRP ma nā ʻili ʻili o ka poʻe maʻi vitiligo e pili ana i nā molekele α Adhesion i hūnā ʻia e nā granules e pili ana i ka hoʻomaikaʻi ʻana i ka microenvironment kūloko o nā maʻi vitiligo e nā cytokines.ʻO ka hoʻomaka ʻana o ka vitiligo e pili kokoke ana i ka pale ʻole o ka ʻili ʻili.Ua ʻike nā haʻawina e pili ana nā maʻi kūlohelohe kūloko o nā maʻi vitiligo i ka hiki ʻole o nā keratinocytes a me nā melanocytes i loko o nā ʻili ʻili e pale aku i ka pōʻino o nā melanocytes i hoʻokumu ʻia e nā ʻano mea inflammatory a me nā chemokines i hoʻokuʻu ʻia i ke kaʻina o ka intracellular oxidative stress.Eia nō naʻe, ʻo nā ʻano mea ulu platelet i huna ʻia e PRP a me nā ʻano cytokine anti-inflammatory i hoʻokuʻu ʻia e nā platelets, e like me ka soluble tumor necrosis factor receptor I, IL-4 a me IL-10, he mau mea kūʻē i ka interleukin-1 receptor, pāʻani i kekahi kuleana i ka hoʻoponopono ʻana i ke kaulike kūloko o nā ʻili ʻili.
（Paʻi hou ʻia nā mea o kēia ʻatikala, ʻaʻole mākou e hāʻawi i ka hōʻoiaʻiʻo a i ʻole ka hōʻoia ʻana no ka pololei, hilinaʻi a i ʻole ka piha o nā mea i loko o kēia ʻatikala, a ʻaʻole kuleana no nā manaʻo o kēia ʻatikala, e ʻoluʻolu e hoʻomaopopo.)
Ka manawa hoʻouna: Nov-24-2022