Hoʻohana i ka PRP Therapy i ka mālama ʻana iā AGA

Platelet Rich Plasma (PRP)

Ua hoʻokipa ʻo PRP i ka manaʻo no ka mea aia nā ʻano mea ulu like ʻole, a hoʻohana nui ʻia i ka ʻoki maxillofacial, orthopedics, plastic surgery, ophthalmology a me nā kula ʻē aʻe.Ma 2006, Uebel et al.Ua ho'āʻo mua e hoʻomaʻamaʻa mua i nā ʻāpana follicular e hoʻololi ʻia me ka PRP a ʻike ʻia i ka hoʻohālikelike ʻia me ka ʻāpana hoʻomalu o ke poʻo, ua ola ka PRP-treated hair transplant area i 18.7 follicular units/cm2, aʻo ka pūʻulu mana i ola 16.4 follicular units./cm2, ua hoʻonui ʻia ka mānoanoa e 15.1%.No laila, ua manaʻo ʻia ʻo nā mea ulu i hoʻokuʻu ʻia e nā platelets e hana i nā pūnaewele o ka lauoho follicle bulge, e hoʻoulu i ka ʻokoʻa o nā pūnaewele a hoʻoikaika i ke kūkulu ʻana i nā kīʻaha koko hou.

I ka makahiki 2011, Takikawa et al.hoʻohana ʻia ka paʻakai maʻamau, PRP, heparin-protamine microparticles i hui pū ʻia me PRP (PRP&D/P MPs) i ka hoʻokele subcutaneous o nā maʻi AGA e hoʻonohonoho i nā mana.Ua hōʻike ʻia nā hopena ua hoʻonui nui ʻia ka ʻāpana cross-sectional o ka lauoho i ka hui PRP a me ka hui PRP&D/P MPs, ua hoʻonui ʻia nā collagen fibers a me nā fibroblasts i nā follicles lauoho ma lalo o ka microscope, a me nā kīʻaha koko a puni ka ua hoʻonui ʻia nā follicles lauoho.

He waiwai nui ka PRP i nā mea ulu ulu platelet.Hoʻoponopono kēia mau protein koʻikoʻi i ka neʻe ʻana o ka cell, hoʻopili, proliferation, a me ka ʻokoʻa, hoʻoikaika i ka hōʻiliʻili ʻana o ka matrix extracellular, a me nā mea ulu he nui e hoʻoikaika i ka ulu ʻana o ka lauoho: nā mea ulu i ka PRP e launa pū me nā follicles lauoho.ʻO ka hui pū ʻana o nā puʻupuʻu puʻupuʻu puʻupuʻu e hoʻoulu i ka hoʻonui ʻana o nā follicles lauoho, hoʻohua i nā ʻāpana follicular, a hoʻoikaika i ka ulu hou ʻana o ka lauoho.Eia kekahi, hiki iā ia ke hoʻoulu i ka hopena cascade downstream a hoʻoikaika i ka angiogenesis.

ʻO ke kūlana o PRP i kēia manawa i ka mālama ʻana iā AGA

ʻAʻohe manaʻo kuʻikahi ma ke ʻano o ka hoʻomākaukau ʻana a me ka platelet enrichment factor o PRP;ʻokoʻa ke ʻano o ka mālama ʻana i ka nui o nā lāʻau lapaʻau, ka manawa waena, ka manawa hoʻihoʻi, ke ʻano o ka injection, a inā paha e hoʻohana ʻia nā lāʻau i hui ʻia.

Mapar et al.ua komo pū me 17 mau kāne maʻi me ka pae IV a VI (Hamilton-Norwood staging method), a ʻaʻole i hōʻike ʻia nā hopena i ka ʻokoʻa ma waena o ka PRP a me ka placebo injections, akā ʻo ke aʻo ʻana i hoʻokō ʻia i 2 injections, a ua liʻiliʻi ka helu o nā lāʻau.Hiki ke nīnau i nā hopena.;

Ua ʻike ʻo Gkini et al i nā maʻi me ka pae haʻahaʻa i hōʻike i ka pane kiʻekiʻe i ka mālama PRP;Ua hōʻoia ʻia kēia ʻike e Qu et al, ʻo ia ka 51 kāne a me 42 mau maʻi wahine me ka pae II-V i nā kāne a me I i nā wahine ~ Stage III (staging is Hamilton-Norwood and Ludwig staging method), ua hōʻike nā hopena i ka mālama ʻana o PRP. ʻO nāʻokoʻa koʻikoʻi nui i nā maʻi me nāʻano likeʻole o nā kāne a me nā wāhine, akā,ʻoi aku ka maikaʻi o ka maikaʻi o ka pae haʻahaʻa a me ke kūlana kiʻekiʻe, no laila, ua mālamaʻia e nā mea noiʻi II , Stage III nā kāne maʻi a me ka pae I wahine maʻi i mālamaʻia me PRP.

Mea Hoonui Pono

ʻO nā ʻokoʻa o ka hoʻomākaukau ʻana o ka PRP i kēlā me kēia haʻawina i alakaʻi ʻia i nā papa hoʻonui like ʻole o ka PRP i kēlā me kēia haʻawina, ʻo ka hapa nui o ia mau mea i hoʻopaʻa ʻia ma waena o 2 a me 6 mau manawa.Hoʻokuʻu ka platelet degranulation i ka nui o nā mea ulu, hoʻoponopono i ka neʻe ʻana o ke kelepona, hoʻopili, hoʻonui a me ka ʻokoʻa, hoʻoulu i ka hoʻonui ʻana o ka lauoho follicle cell, tissue vascularization, a hoʻoikaika i ka hōʻiliʻili ʻana o ka matrix extracellular.I ka manawa like, ua manaʻo ʻia ke ʻano o ka microneedling a me ka laser therapy haʻahaʻa haʻahaʻa e hana i ka pōʻino o ke kino a hoʻoulu i ke kaʻina degranulation platelet kūlohelohe, e hoʻoholo ana i ka maikaʻi o ka huahana o PRP ma muli o kāna hana biological.No laila, he mea koʻikoʻi ka ʻimi ʻana i ka manaʻo kūpono o PRP.Manaʻo kekahi mau haʻawina e ʻoi aku ka maikaʻi o ka PRP me ka hoʻonui ʻana i nā manawa 1-3 ma mua o kahi papa hoʻonui kiʻekiʻe, akā ʻo Ayatollahi et al.hoʻohana i ka PRP me ka hoʻonuiʻana i nā manawa 1.6 no ka mālamaʻana, a ua hōʻike nā hopena i ka maikaʻiʻole o ka mālamaʻana i nā maʻi AGA, a ua manaʻoʻiʻoʻo PRP ʻO ka manaʻo kūpono he 4 ~ 7 manawa.

Ka helu o nā lapaʻau, ka manawa waena a me ka manawa hoʻomaha

ʻO nā haʻawina o Mapar et al.a me Puig et al.ua loaʻa nā hopena maikaʻi ʻole.ʻO ka nui o nā lāʻau lapaʻau PRP i kēia mau protocol haʻawina ʻelua he 1 a me 2 mau manawa, ʻoi aku ka haʻahaʻa ma mua o nā haʻawina ʻē aʻe (ka hapa nui o 3-6 mau manawa).Picard et al.Ua ʻike ʻia ua hōʻea ka maikaʻi o ka PRP i kona kiʻekiʻe ma hope o 3 a 5 mau lāʻau lapaʻau, no laila ua manaʻo lākou he ʻoi aku ma mua o 3 mau lapaʻau e pono ai e hoʻomaikaʻi i nā hōʻailona o ka nalowale o ka lauoho.

Ua ʻike ʻia ka loiloi ʻo Gupta a me Carviel ʻo ka hapa nui o nā haʻawina i loaʻa i nā manawa lapaʻau o 1 mahina, a ma muli o ka helu palena o nā haʻawina, ʻaʻole i hoʻohālikelike ʻia nā hopena o ka mālama ʻana me nā inikini PRP o kēlā me kēia mahina me nā alapine injection ʻē aʻe, e like me nā inikini PRP i kēlā me kēia pule.

Ua hōʻike ʻia kahi haʻawina a Hausauer a me Jones [20] i nā poʻe i loaʻa i kēlā me kēia mahina i ʻoi aku ka maikaʻi o ka helu o ka lauoho i hoʻohālikelike ʻia i ka pinepine o nā injections i kēlā me kēia 3 mahina (P<0.001);ʻO Schiavone et al.[21] ua hoʻoholo ʻia, pono e hana hou ʻia ka lāʻau lapaʻau 10 a 12 mau mahina ma hope o ka pau ʻana o ka papa o ka mālama ʻana;Gentile et al.hahai 'ia no 2 makahiki, ka lōʻihi loa o ka hahai ana ma waena o nā haʻawina a pau, a ua ike i kekahi poe maʻi relapsed i 12 mahina (4/20 hihia), a ma 16 maʻi Symptoms ua oi 'ōlelo i loko o nā mahina.

Ma ka hahai ʻana o Sclafani, ua ʻike ʻia ua emi nui ka maikaʻi o nā maʻi ma hope o 4 mau mahina ma hope o ka pau ʻana o ka papa hana.Picard et al.kuhikuhi i nā hopena a hāʻawi i nā ʻōlelo aʻo e pili ana i ka mālama ʻana: ma hope o ka wā maʻamau o 3 mau mālama ʻana o 1 mahina, pono e hana ʻia ka mālama ʻana i kēlā me kēia 3 manawa.Lapaʻau koʻikoʻi o kēlā me kēia mahina.Eia naʻe, ʻaʻole i wehewehe ʻo Sclafani i ka ratio platelet enrichment ratio o nā mea hoʻomākaukau i hoʻohana ʻia i ke kaʻina hana.I loko o kēia haʻawina, ua hoʻomākaukau ʻia ka 8-9 ml o ka platelet-rich fibrin matrix matrix mai 18 ml o ke koko peripheral (ua hoʻohui ʻia ka PRP i unuhi ʻia i loko o kahi pahu ʻūhā CaCl2, a ua kau ʻia ka fibrin glue i loko o kahi fibrin glue. injection ma mua o ka hoʻokumu ʻana) , ke manaʻoʻiʻo nei mākou ʻaʻole lawa ka hoʻonui ʻana o nā platelets i kēia hoʻomākaukau ʻana, a ʻoi aku ka nui o nā hōʻike e kākoʻo ai.

Keʻano hoʻopiʻi

ʻO ka hapa nui o ke ʻano o ka injection he intradermal injection a subcutaneous injection.Ua kūkākūkā nā mea noiʻi i ka hopena o ke ʻano hoʻokele i ka hopena curative.Ua ʻōlelo ʻo Gupta lāua ʻo Carviel i ka hoʻokele subcutaneous.Hoʻohana kekahi mau mea noiʻi i ka injection intradermal.Hiki i ka Intradermal injection ke hoʻopaneʻe i ke komo ʻana o ka PRP i loko o ke koko, hoʻemi i ka helu metabolic, hoʻolōʻihi i ka manawa o ka hana kūloko, a hoʻonui i ka hoʻoulu ʻana o ka dermis e hoʻoikaika i ka ulu lauoho.ʻaʻole like ka hohonu.Manaʻo mākou e hoʻohana pono ʻia ka ʻenehana Nappage i ka wā e hana ai i nā injections intradermal e kāpae i ka mana o nā ʻokoʻa injection, a ke paipai nei mākou i nā poʻe maʻi e kahi i ko lākou lauoho pōkole e nānā i ke kuhikuhi o ka lauoho, a hoʻoponopono i ke kihi hoʻokomo pono e like me kāna. ʻO ka ulu ʻana o ka ulu ʻana i hiki ai i ka piko o ka nila a puni ka follicle lauoho, ma laila e hoʻonui ai i ka manaʻo PRP kūloko i ka follicle lauoho.ʻO kēia mau ʻōlelo aʻoaʻo e pili ana i nā ʻano hana injection no ka ʻike wale nō, no ka mea, ʻaʻohe haʻawina e hoʻohālikelike pololei i nā pono a me nā hemahema o nā ʻano hana injection.

Hoʻoponopono Hoʻohui

Jha et al.ua hoʻohana ʻia ka PRP i hui pū ʻia me ka microneedling a me ka 5% minoxidil hui pū ʻana i ka lāʻau lapaʻau e hōʻike i ka maikaʻi maikaʻi ma nā hōʻike pahuhopu ʻelua a me ka loiloi pilikino hoʻomanawanui.Ke kū nei mākou i nā pilikia i ka hoʻoponopono ʻana i nā regimen lapaʻau no PRP.ʻOiai ʻo ka hapa nui o nā haʻawina e hoʻohana ana i nā ʻano qualitative a me quantitative e loiloi i ka hoʻomaikaʻi ʻana o nā hōʻailona ma hope o ka mālama ʻana, e like me ka helu lauoho hope, helu lauoho vellus, helu lauoho, density, mānoanoa, a me nā mea ʻē aʻe, ʻokoʻa nā ʻano loiloi;Eia kekahi, ka hoʻomākaukau ʻana o PRP ʻAʻohe kūlana kūlike ma ke ʻano o ke ʻano, hoʻohui i ka activator, ka manawa centrifugation a me ka wikiwiki, platelet concentration, etc.;ʻokoʻa nā ʻano hana lapaʻau i ka helu o nā lāʻau lapaʻau, ka manawa waena, ka manawa hoʻihoʻi, ke ʻano o ka injection, a inā paha e hui pū i ka lāʻau;ʻO ke koho ʻana i nā laʻana i loko o ke aʻo ʻana ʻaʻole ʻo Stratification e ka makahiki, ke kāne, a me ke degere o ka alopecia i hoʻopili hou i ka loiloi o nā hopena lapaʻau PRP.I ka wā e hiki mai ana, ʻoi aku ka nui o nā haʻawina hoʻomalu ponoʻī e pono e hoʻomaʻamaʻa i nā ʻāpana lapaʻau like ʻole, a hiki ke hoʻomaikaʻi maikaʻi ʻia ka loiloi stratified o nā kumu e like me ka makahiki o ka maʻi, ke kāne, a me ke degere o ka lilo o ka lauoho.

（Paʻi hou ʻia nā mea o kēia ʻatikala, ʻaʻole mākou e hāʻawi i ka hōʻoiaʻiʻo a i ʻole ka hōʻoia ʻana no ka pololei, hilinaʻi a i ʻole ka piha o nā mea i loko o kēia ʻatikala, a ʻaʻole kuleana no nā manaʻo o kēia ʻatikala, e ʻoluʻolu e hoʻomaopopo.)