ʻO Androgenic alopecia (AGA), ke ʻano maʻamau o ka poho o ka lauoho, he maʻi pohō lauoho holomua e hoʻomaka ana i ka wā ʻōpio a i ʻole ka wā ʻōpio.ʻO ka nui o nā kāne ma koʻu ʻāina ma kahi o 21.3%, a ʻo ka nui o nā wahine ma kahi o 6.0%.ʻOiai ua manaʻo kekahi poʻe loea i nā alakaʻi no ka ʻike a me ka mālama ʻana i ka androgenetic alopecia ma Kina i ka wā ma mua, ʻoi aku ka nui o ka nānā ʻana i ka maʻi a me ka mālama ʻana i ka AGA, a ʻo nā koho lapaʻau ʻē aʻe i nele.I nā makahiki i hala iho nei, me ka manaʻo nui i ka mālama ʻana i ka AGA, ua puka mai kekahi mau koho lapaʻau hou.
Etiology a me Pathogenesis
ʻO AGA kahi maʻi maʻi polygenic recessive genetically predisposed.Hōʻike nā noiʻi epidemiological home he 53.3% -63.9% o nā maʻi AGA he moʻolelo ʻohana, a ʻoi aku ka kiʻekiʻe o ka laina makua ma mua o ka laina makuahine.Ua ʻike nā haʻawina holoʻokoʻa holoʻokoʻa-genome a me ka hoʻopaʻa palapala ʻana i kekahi mau genes susceptibility, akā ʻaʻole i ʻike ʻia ko lākou mau ʻano pathogenic.Hōʻike nā noiʻi o kēia manawa he hana koʻikoʻi nā androgens i ka pathogenesis o AGA;ʻO nā kumu'ē aʻe e like me ka mumū a puni ka lauoho lauoho, ka piʻiʻana o ke ola, ka haʻalulu a me ka hopohopo, a me ka noho maikaʻiʻole a me kaʻaiʻana e hiki ke hoʻonui i nā hōʻailona o AGA.ʻO nā Androgens i loko o nā kāne mai ka testosterone huna ʻia e nā hōʻike;ʻO nā androgens i loko o nā wahine ka mea nui mai ka synthesis o adrenal cortex a me kahi liʻiliʻi o ka huna ʻana mai nā ovaries, ʻo ka androgen ka nui o androstenediol, hiki ke hoʻololi ʻia i testosterone a me dihydrotestosterone.ʻOiai he kumu nui nā androgens i ka pathogenesis o AGA, ua mālama ʻia nā pae androgen e holo ana ma kahi o nā maʻi AGA āpau i nā pae maʻamau.Ua hōʻike ʻia nā haʻawina e hoʻonui ʻia ka hopena o nā androgens i nā follicles lauoho ma muli o ka hoʻonui ʻana i ka hōʻike gene receptor androgen a / a i ʻole ka hoʻonui ʻia ʻana o ke ʻano II 5α reductase gene i loko o nā follicles lauoho ma ka wahi alopecia.No ka AGA, aia nā ʻāpana dermal o nā follicles lauoho maʻalahi i kahi ʻano II 5α reductase, hiki ke hoʻohuli i ka testosterone androgen e holo ana i ka wahi i loko o ke koko i dihydrotestosterone ma o ka hoʻopaʻa ʻana i ka intracellular androgen receptor.Ke hoʻomaka nei i kahi ʻano o nā hopena e alakaʻi ana i ka miniaturization holomua o nā follicles lauoho a me ka lauoho lauoho i ka ʻōhule.
Nā hōʻike lapaʻau a me nā manaʻo lapaʻau
ʻO ka AGA kahi ʻano alopecia non-scarring e hoʻomaka maʻamau i ka wā ʻōpio a ua ʻike ʻia e ka lahilahi o ka lauoho lauoho, ka nalowale o ka nui o ka lauoho, a me ka alopecia a hiki i nā ʻano ʻokoʻa o ka ʻōhule, e hele pū ʻia me nā hōʻailona o ka hoʻonui ʻia ʻana o ka ʻaila poʻo.
Noi PRP
Ua like ka pae platelet me ka concentrate o 4-6 mau manawa o ka platelet concentration i loko o ke koko holoʻokoʻa.I ka manawa e ho'ālaʻia ai ka PRP, e hoʻokuʻu ka α granules i loko o nā platelets i ka nui o nā mea ulu, e like me ka platelet-derrived growth factor, transforming growth factor-β, insulin-like growth factor, epidermal growth factor a me vascular endothelial growth factor, etc. o ka paipai ʻana i ka ulu ʻana o ka lauoho, akā ʻaʻole maopopo loa ke ʻano o ka hana.ʻO ka hoʻohana ʻana e hoʻokomo i ka PRP kūloko i loko o ka papa dermis o ke poʻo i ka ʻāpana alopecia, hoʻokahi manawa i ka mahina, a ʻo ka hoʻomau mau ʻana i ka 3 a 6 mau manawa hiki ke ʻike i kekahi hopena.ʻOiai ua hōʻoia mua nā haʻawina hauʻoli like ʻole ma ka home a me nā ʻāina ʻē he hopena ko PRP i ka AGA, ʻaʻohe ʻano maʻamau no ka hoʻomākaukau ʻana i ka PRP, no laila ʻaʻole kūlike ka helu kūpono o ka mālama ʻana i ka PRP, a hiki ke hoʻohana ʻia ma ke ʻano he kōkua. ʻo ia hoʻi no ka mālama ʻana i ka AGA ma kēia pae.
（Paʻi hou ʻia nā mea o kēia ʻatikala, ʻaʻole mākou e hāʻawi i ka hōʻoiaʻiʻo a i ʻole ka hōʻoia ʻana no ka pololei, hilinaʻi a i ʻole ka piha o nā mea i loko o kēia ʻatikala, a ʻaʻole kuleana no nā manaʻo o kēia ʻatikala, e ʻoluʻolu e hoʻomaopopo.)
Ka manawa hoʻouna: ʻAukake-02-2022