E pili ana i ka Platelet Rich Plasma (PRP)
Platelet-rich plasma (PRP) ua like ka waiwai therapeutic i nā pūnaewele stem a i kēia manawa ʻo ia kekahi o nā mea lapaʻau maikaʻi loa i ka lāʻau lapaʻau regenerative.Hoʻohana nui ʻia i nā lāʻau lapaʻau like ʻole, me ka cosmetic dermatology, orthopedics, lāʻau lapaʻau haʻuki a me ke ʻoki.
I ka makahiki 1842, ua ʻike ʻia nā hale ʻē aʻe ma waho o ke koko ʻulaʻula a me ke keʻokeʻo, kahi i kāhāhā ai kona mau hoa.ʻO Julius Bizozero ka mea mua i kapa inoa i ke ʻano platelet hou "le piastrine del sangue" - platelets.I ka makahiki 1882, ua wehewehe ʻo ia i ke kuleana o nā platelets i ka coagulation in vitro a me ko lākou komo ʻana i ka etiology o ka thrombosis in vivo.Ua ʻike pū ʻo ia ʻo nā paia kīʻaha koko ke kāohi i ka platelet adhesion.Ua holomua hou ʻo Wright i ka hoʻomohala ʻana i nā ʻenehana hoʻōla hou me kāna ʻike ʻana i nā macrokaryocytes, ʻo ia nā mea mua o nā platelets.I nā makahiki 1940 mua, ua hoʻohana nā kauka i nā "extracts" embryonic i haku ʻia me nā kumu ulu a me nā cytokines e hāpai i ka hoʻōla ʻana i ka ʻeha.He mea koʻikoʻi ka ho'ōla wikiwiki a me ka maikaʻi i ka holomua o nā kaʻina hana.No laila, ʻo Eugen Cronkite et al.ua hoʻokomo i ka hui pū ʻana o ka thrombin a me ka fibrin i nā ʻili ʻili.Ma ka hoʻohana ʻana i nā ʻāpana i luna, ua hōʻoia ʻia kahi paʻa paʻa a paʻa o ka flap, kahi mea nui i kēia ʻano o ka ʻoki.
I ka hoʻomaka ʻana o ke kenekulia 20, ua ʻike nā kauka i ka pono wikiwiki e hoʻokomo i ka transfusion platelet e mālama i ka thrombocytopenia.Ua alakaʻi kēia i ka hoʻomaikaʻi ʻana i nā ʻenehana hoʻomākaukau platelet concentrate.ʻO ka hoʻohui ʻana me nā platelet concentrates hiki ke pale i ke koko i nā maʻi.I kēlā manawa, ua hoʻāʻo nā kauka a me nā hematologists laboratory e hoʻomākaukau i nā platelet concentrates no ka hoʻololi ʻana.ʻO nā ala e loaʻa ai ka concentrates ua ulu wikiwiki a ua hoʻomaikaʻi nui ʻia, no ka mea, ua nalowale nā palapala kaʻawale i ko lākou ola a no laila pono e mālama ʻia ma 4 ° C a hoʻohana ʻia i loko o 24 mau hola.
Nā mea a me nā ʻano hana
I ka makahiki 1920, ua hoʻohana ʻia ka citrate ma ke ʻano he anticoagulant no ka loaʻa ʻana o nā platelet concentrates.Ua wikiwiki ka holomua o ka hoʻomākaukau ʻana i nā platelet concentrates i nā makahiki 1950 a me 1960 i ka wā i hana ʻia ai nā ipu koko plastik maʻalahi.Ua hoʻohana mua ʻia ka huaʻōlelo "platelet-rich plasma" e Kingsley et al.i ka makahiki 1954 e nānā i nā platelet concentrates maʻamau i hoʻohana ʻia no ka hoʻokahe koko.Ua ʻike ʻia nā palapala PRP panakō koko mua i nā makahiki 1960 a ua kaulana i nā makahiki 1970.I ka hopena o ka makahiki 1950 a me ka makahiki 1960, ua hoʻohana ʻia ka "EDTA platelet packs".Aia i loko o ka pūʻulu kahi ʻeke plastik me ke koko EDTA e hiki ai i nā platelets ke hoʻopaʻa ʻia e ka centrifugation, e hoʻomau ʻia i loko o kahi liʻiliʻi o ka plasma ma hope o ke kaʻina.
Ka hopena
Manaʻo ʻia ʻo nā mea ulu (GFs) he mau pūhui hou aʻe o PRP i hūnā ʻia mai nā platelets a komo i kāna hana.Ua hōʻoia ʻia kēia kuhiakau i ka makahiki 1980.ʻIke ʻia e hoʻokuʻu nā platelets i nā molekole bioactive (GFs) e hoʻoponopono i ka ʻiʻo i poino, e like me ka ʻeha ʻili.I kēia lā, ua hana ʻia kekahi mau haʻawina e ʻimi ana i kēia pilikia.ʻO kekahi o nā kumuhana i aʻo nui ʻia ma kēia kahua ʻo ka hui pū ʻana o PRP a me hyaluronic acid.Ua ʻike ʻia ʻo Epidermal growth factor (EGF) e Cohen i ka makahiki 1962. ʻO nā GF ma hope mai he platelet-derived growth factor (PDGF) i ka makahiki 1974 a me ka vascular endothelial growth factor (VEGF) i ka makahiki 1989.
ʻO ka holoʻokoʻa, ʻo ka holomua o ka lāʻau lapaʻau i alakaʻi i ka holomua wikiwiki i nā noi platelet.I ka makahiki 1972, ua hoʻohana mua ʻo Matras i nā platelets ma ke ʻano he sealant e hoʻokumu i ka homeostasis koko i ka wā o ke kaʻina.Eia kekahi, i ka makahiki 1975, ʻo Oon lāua ʻo Hobbs nā kānaka ʻepekema mua i hoʻohana i ka PRP i ka lāʻau lapaʻau hou.I ka makahiki 1987, ua hoʻohana mua ʻo Ferrari et al i ka plasma waiwai platelet ma ke ʻano he kumu autologous o ke kahe koko i ka ʻoki ʻana i ka naʻau, a laila e hōʻemi ana i ke kahe koko intraoperative, nā maʻi koko o ka holo ʻana o ka pulmonary peripheral, a me ka hoʻohana ʻana i nā huahana koko.
I ka makahiki 1986, Knighton et al.ʻO ia ka poʻe ʻepekema mua i wehewehe i kahi protocol hoʻonui platelet a kapa ʻia ʻo ia autologous platelet-derived wound healing factor (PDWHF).Mai ka hoʻokumu ʻana o ka protocol, ua hoʻohana nui ʻia ka ʻenehana i ka lāʻau lapaʻau aesthetic.Ua hoʻohana ʻia ʻo PRP i ka lāʻau lapaʻau regenerative mai ka hopena o 1980s.
Ma waho aʻe o ke kaʻina hana maʻamau a me ka hōʻoki ʻana i ka naʻau, ʻo ka ʻoki maxillofacial kahi wahi ʻē aʻe kahi i kaulana ai ka PRP i nā makahiki 1990.Ua hoʻohana ʻia ʻo PRP no ka hoʻomaikaʻi ʻana i ka hoʻopaʻa ʻana i ka hoʻopaʻa ʻana i ka mandibular reconstruction.Ua hoʻomaka ʻia ka PRP e hoʻokō i nā niho niho a ua hoʻohana ʻia mai ka hopena o nā makahiki 1990 e hoʻomaikaʻi i ka hoʻopaʻa ʻana o nā implants niho a me ka hoʻoikaika ʻana i ka iwi hou.Eia kekahi, ʻo ka fibrin glue kekahi mea pili i hoʻolauna ʻia i kēlā manawa.Ua hoʻomohala hou ʻia ka hoʻohana ʻana i ka PRP i ka lāʻau niho me ka hana ʻana o ka platelet-rich fibrin (PRF), kahi platelet concentrate ʻaʻole pono e hoʻohui i nā anticoagulants, e Choukroun.
Ua kaulana ʻo PRF i nā makahiki 2000, me ka hoʻonui nui ʻana o nā noi i nā kaʻina hana niho, me ka hoʻolaʻa hou ʻana o ka ʻiʻo gingival hyperplastic a me nā defects periodontal, pani ʻana i ka palatal palatal, ka mālama ʻana o ka gingival, a me nā lima unuhi.
Kūkākūkā
Ua wehewehe ʻo Anitua i ka makahiki 1999 i ka hoʻohana ʻana i ka PRP e hāpai i ka hoʻōla hou ʻana o ka iwi i ka wā o ka hoʻololi plasma.Ma hope o ka nānā ʻana i nā hopena maikaʻi o ka lāʻau lapaʻau, ua noiʻi hou nā ʻepekema i kēia hanana.Ua hōʻike ʻia kāna mau pepa hope i ka hopena o kēia koko ma luna o nā ʻeha ʻili mau loa, ka hoʻokomo ʻana i nā niho, ka hoʻōla ʻana o ka tendon, a me nā ʻeha haʻuki orthopedic.Ua hoʻohana ʻia kekahi mau lāʻau lapaʻau e hoʻāla i ka PRP, e like me ka calcium chloride a me ka bovine thrombin, mai ka makahiki 2000.
Ma muli o kāna mau waiwai maikaʻi, hoʻohana ʻia ka PRP i nā orthopedics.Ua paʻi ʻia nā hopena o ka noiʻi hohonu mua o nā hopena o ka ulu ʻana o ke kino o ke kanaka i ka 2005. Hoʻohana ʻia ka PRP therapy i kēia manawa no ka mālama ʻana i nā maʻi degenerative a me ka hoʻoikaika ʻana i ka ho'ōla ʻana o nā tendons, ligaments, muscles and cartilage.Hōʻike ka noiʻi e pili ana ka kaulana kaulana o ke kaʻina hana i nā orthopedics i ka hoʻohana pinepine ʻana o PRP e nā hōkū haʻuki.I ka makahiki 2009, ua paʻi ʻia kahi noiʻi holoholona hoʻokolohua e hōʻoia ana i ke kuhiakau e hoʻoikaika ʻo PRP i ka hoʻōla ʻana i ka ʻiʻo.ʻO ke kumu kumu o ka hana PRP i ka ʻili i kēia manawa ke kumuhana o ka noiʻi ʻepekema koʻikoʻi.
Ua hoʻohana maikaʻi ʻia ʻo PRP i ka dermatology cosmetic mai 2010 a i ʻole ma mua.Ma hope o ka hoʻokomo ʻana i ka PRP, ʻoi aku ka ʻōpio o ka ʻili a hoʻomaikaʻi maikaʻi ʻia ka hydration, ka maʻalahi a me ke kala.Hoʻohana pū ʻia ʻo PRP e hoʻomaikaʻi i ka ulu ʻana o ka lauoho.ʻElua ʻano PRP i hoʻohana ʻia i kēia manawa no ka mālama ʻana i ka lauoho - inactive platelet-rich plasma (A-PRP) a me ka platelet-rich plasma (AA-PRP).Eia naʻe, ʻo Gentile et al.ua hōʻike ʻia e hiki ke hoʻomaikaʻi ʻia ka nui o ka lauoho a me ka helu ʻana o ka lauoho ma o ka hoʻokomo ʻana iā A-PRP.Eia kekahi, ua hōʻike ʻia ʻo ka hoʻohana ʻana i ka mālama PRP ma mua o ka hoʻololi ʻana o ka lauoho hiki ke hoʻonui i ka ulu lauoho a me ka lauoho lauoho.Eia kekahi, i ka makahiki 2009, ua hōʻike nā haʻawina i ka hoʻohana ʻana i ka hui ʻana o ka PRP a me ka momona hiki ke hoʻomaikaʻi i ka ʻae ʻana o ka graft graft a me ke ola ʻana, hiki ke hoʻomaikaʻi i nā hopena o ka ʻokiʻoki.
ʻO nā ʻike hou loa mai Cosmetic Dermatology e hōʻike ana i ka hui pū ʻana o ka PRP a me ka CO2 laser therapy hiki ke hōʻemi nui i nā ʻeleʻele.Pēlā nō, ʻo ka PRP a me ka microneedling ka hopena i ʻoi aku ka maikaʻi o nā pūpū collagen i ka ʻili ma mua o ka PRP wale nō.ʻAʻole pōkole ka moʻolelo o PRP, a he mea nui nā ʻike e pili ana i kēia ʻāpana koko.Ke ʻimi nei nā kauka lapaʻau a me nā ʻepekema i nā ʻano hana lapaʻau hou.Ma ke ʻano he kumu, hoʻohana ʻia ʻo PRP i nā ʻano lāʻau lapaʻau, me ka gynecology, urology, a me ka ophthalmology.
ʻO ka moʻolelo o PRP ma kahi o 70 mau makahiki.No laila, ua hoʻokumu maikaʻi ʻia ke ʻano a hiki ke hoʻohana nui ʻia i ka lāʻau lapaʻau.
（Paʻi hou ʻia nā mea o kēia ʻatikala, ʻaʻole mākou e hāʻawi i ka hōʻoiaʻiʻo a i ʻole ka hōʻoia ʻana no ka pololei, hilinaʻi a i ʻole ka piha o nā mea i loko o kēia ʻatikala, a ʻaʻole kuleana no nā manaʻo o kēia ʻatikala, e ʻoluʻolu e hoʻomaopopo.)
Ka manawa hoʻouna: Iulai-28-2022